-As was already mentioned, Grim Dawn certainly seems to be a game worth picking up, but unfortunately it isn't due for release until the latter half of 2013, if not later.
-IMO, Borderlands 2 looks like it'll be loads of fun, even if it isn't exactly a traditional isometric ARPG.
-Of course, there is Diablo 3, but after having put a fair amount of time into the game, all I wanted to do was to re-install Diablo 2: LoD. Still, I'll keep playing until I reach Inferno, as that difficulty is supposed to be ridiculously hard.
-Torchlight 2, also mentioned above, seems to have plenty of promise. I managed to play the beta for a few hours (got a beta key on the final day of testing, which left me about 4 hours to install and play), and I enjoyed the game, but from what I've read, there are balance issues when it comes to the playable classes; hopefully that gets ironed out somewhat over the first handful of patches.
-Finally, as others have advocated, Sacred 2 itself is certainly well worth revisiting. I recently started playing the game again, thanks to its broad variety of viable and strange builds, something that I really missed in a game like Diablo 3.