However, I've found Speed Lore useful when it does get picked. Beyond the run speed boost (which probably works better on console, between the control scheme benefits and non-nerfed All Skills+ synergy), I've found the Attack Value bonus from Speed Lore extremely useful for keeping an extremely high accuracy. In exchange, I can use the sockets for other purposes (instead of accuracy boosting bonuses).
Also, remember that "overkill" in an earlier difficulty may become insufficient in a higher difficulty. For example: I noticed the gains of the Attack Value+ with the DW Seraphim that I've been posting the experience/second tests with. When she first entered Niob, her hit-rate dropped below 90%. However, when I pushed Speed Lore to Mastery, her hit-rate jumped above 95% (across multiple tests) and her kill speed increased drastically as a result. This particular character has little All Skills+, due to filling as many sockets as possible with Experience Per Kill+.
I'll leave the "Spell Resistance vs. Toughness" question for someone who has more experience with the PC version. On console, Spell Resistance is pretty much worthless.
Edited by Mystix123, 18 May 2013 - 07:49 PM.