Okay, I'm just gonna say right now that I always appreciated the free camera in SR2. When I play games in a locked isometric view, I have to remind myself that I don't have the luxury of a 360 spin for my view.
Okay, that's out of the way...you know my bias.
I actually like what I read about them going with a hand-drawn world. Some of those adventure games (point and click style) have some incredible artwork and while they aren't necessarily a game style I particularly enjoy, I have bought a couple simply on the basis of liking the artwork.
Now I am imagining something similar to that, only with the gameplay style of an ARPG, and I think my preference for a free camera can be ignored. It's a bold idea and will help to create a distinctive style for them to establish this new property. It's an incredibly cool idea and I can't even fathom how much work it will be to do it, but I think that the creative potential for it will make it worthwhile.
Hadn't actually reconciled that a drawn look like this would mean they could actually get away quite successfully with a non 3d world.
We're going to get a lof of peeps voicing objections over this though, as I know a fair number of peeps think that 3d is a "must have"... but in a case like this, if looking for something fresh, and that can pay homage to, the old game, I think this can definitely be a strength.