On my L162 Seraphim: Sitting at +795.3% Shield Energy (has another +71.3% listed below in the sigma, not sure why it gets listed twice with different values), well over 100 in Warding Energy Lore due to the various +skills modifiers in my gear, several things like Testa's Band in slots (plus a very nice yellow amulet that gave me a shield recharge bonus and additional % warding energy), over 70 runes eaten for Warding Energy, and with very highly stacked Wisdom + Vitality + Constitution, I am sitting at 67k health & 869k shield.
I ignore putting any stat points into things like Str and Int entirely and rely on a very low cooldown Pelting Strikes for the vast majority of my damage output. Currently dual-wielding a Sneaking Demon and Sanguine Runeblade (and that 6.7s per hit regen from the Sanguine Runeblade combined with Pelting Strikes is sooooooooo good). All of my stat points go into Wis, Dex (all of the stuff like Ancrid's Blade or the two swords I currently use all rely on Dex vs Str), Vit, any leftovers into Stamina.
Mind you, stuff can still bypass shields entirely and directly damage your health, but with this character, as a test, I have gone AFK for 10 minutes at the desert dragon boss and it never dropped my health or shields below 90%. I repeated this test six more times on a ten minute timer at the same boss and it's always at 90% remaining or above when I come back.
Methinks I need a mod to make Niobium three times the difficulty ;)